Tribedoce e na le vithamine B1 (thiamine hydrochloride) , vithamine B12 (hydroxocobalamin) , vithamine B6 (pyridoxine hydrochloride) . E na le phello e ntle ts'ebetsong ea sebete le sistimi ea methapo. E kenya tšireletso ea mali ka tekanyetso e phahameng e baka keketseho ea ts'ebetso ea thromboplastin le prothrombin.
Ketso ea meriana
Tribedoce) e bolela sehlopha sa livithamini tse qhibilihang ka har'a metsi. E na le ts'ebetso e phahameng ea likokoana-hloko. Tribedoce (vithamine B12 (hydroxocobalamin)) ea hlokahala bakeng sa hematopoiesis e tloaelehileng (e khothaletsa ho butsoa ha lisele tse khubelu tsa mali).
E nka karolo ts'ebetsong ea phetisetso, phetiso ea hydrogen, synthesis ea methionine, nucleic acid, choline, creatine. E kenya letsoho ho bokelleng ha li-erythrocyte tsa metsoako e nang le lihlopha tsa sulfhydryl.
Pharmacokinetics
Kamora 'kalafo ea molomo, Tribedoce (vithamine B12 (hydroxocobalamin)) e ananeloa ke pampiri ea meno. Metabolized ka lisele, e fetoha mofuta oa coenzyme - adenosylcobalamin, e leng mofuta o sebetsang oa cyanocobalamin. E ntšitsoe ka bile le moroto.
Hobaneng ha Tribedoce) e laetsoe?
Phokolo ea mali ka lebaka la maemo a khaello ea B12; kalafo e rarahaneng bakeng sa tšepe le mali a morao-mali; khaello ea mali e bakoang ke lintho tse chefo le lithethefatsi; lefu la sebete (lefu la sebete, lefu la ho thatafala ha sebete); myelosis e monate; polyneuritis, radiculitis, neuralgia, amyotrophic lateral sclerosis; lesea la cerebral palsy, Down syndrome, kotsi ea methapo; mafu a letlalo (psoriasis, photodermatosis, dermatitis herpetiformis, neurodermatitis); ho thibela le ho alafa matšoao a Tribedoce (vithamine B12 (hydroxocobalamin)) khaello (ho kenyeletsoa ts'ebeliso ea biguanide, PASA, vithamine C ka tekanyetso e phahameng); ho kula ha radiation.
Tekanyo le tsamaiso
Tribedoce) e sebelisoa e le liente tsa SC, IV, IM, intralumbar le molomo. Ka phokolo ea mali e amanang le khaello ea Tribedoce (vithamine B12 (hydroxocobalamin)) e hlahisoa ho 100-200 mcg ka matsatsi a 2.
Ka phokolo ea mali e nang le matšoao a 'funicular myelosis' le 'megalocytic anemia' le mafu a tsamaiso ea methapo: Li-microgram tsa 400-500 matsatsing a 7 a pele ka letsatsi, ebe nako e le 1 ka matsatsi a 5-7.
Nakong ea tšoarelo ha ho se na ketsahalo ea tlhokomelo ea mokokotlo oa myelosis ea funicular - 100 mcg makhetlo a 2 ka khoeli, boteng ba matšoao a methapo - ho isa ho 200-400 mcg makhetlo a 2-4 ka khoeli.
Ka mali a hlobaetsang ka mor'a hemorrhagic le khaello ea mali ea tšepe ka 30-100 mcg makhetlo a 2-3 ka beke. Ha aplastic anemia (haholo-holo ho bana) - 100 micrograms pele ho ntlafatso ea bongaka.
Ha phokolo ea mali ea masea le masea a tlang pele ho nako - 30 mcg / letsatsi ka matsatsi a 15.
Ho mafu a methapo ea methapo e bohareng le e potileng le maloetse a methapo a nang le lefu la bohloko e tsamaisoa ka litekanyetso tse eketsehang - 200-500 mcg, ka ntlafatso ea mmuso - 100 mcg / letsatsi.
Mokhoa oa kalafo oa Tribedoce (vithamine B12 (hydroxocobalamin) ke libeke tse 2. Ka liso tse bohloko tsa sistimi ea methapo ea kutlo: ho 200-400 mcg letsatsi le leng le le leng bakeng sa matsatsi a 40-45.
Ha lefu la sebete le lefu la ho thatafala ha sebete: 30-60 mcg / letsatsi kapa 100 mg letsatsi le leng le le leng bakeng sa matsatsi a 25-40.
Dystrophy ho bana ba banyenyane, Down syndrome le cerebral palsy: ka 15-30 mcg letsatsi le leng le le leng.
Ha funicular myelosis, amyotrophic lateral sclerosis e ka hlahisoa ka mokokotlong oa 15-30 mcg, butle-butle e eketsa lethal dose ea 200-250 micrograms.
Mafung a radiation, lefu la tsoekere la lefu la tsoekere, le phahama ho 60-100 mcg letsatsi le leng le le leng ka matsatsi a 20-30.
Ha Tribedoce (Vitamin B12 (Hydroxocobalamin)) e haella ho thibela - IV kapa IM bakeng sa 1 mg 1 nako ka khoeli; bakeng sa kalafo: IV kapa IM bakeng sa 1 mg ka letsatsi bakeng sa libeke tse 1-2, lethal dose ke 1-2 mg IV kapa IM bakeng sa 1 ka beke, ho fihlela ho 1 ka khoeli. Nako ea phekolo e khethoa ka bomong.
papatso
Morabe litla-morao tse leshome le metso e 'meli, liphetoho tse mpe
CNS: ka seoelo, boemo ba thabo.
Sisteme ea pelo: ke ka seoelo - bohloko ba pelo, tachycardia.
Liketso tse fokolang: hangata - maheba.
Tribedoce) litemoso
Thromboembolism, erythremia, erythrocytosis, kutloisiso e eketsehileng ho cyanocobalamin.
Tribedoce) nakong ea bokhachane le ho anyesa
Cyanocobalamin e ka sebelisoa nakong ea bokhachane ho latela lipepe.
Litaelo tse khethehileng
Ha stenocardia e lokela ho sebelisoa ka hloko lethalolong le le leng la Tribedoce) 100 mcg. Litšoantšo tsa mali le coagulation li lokela ho hlahlojoa khafetsa nakong ea kalafo. Ha ho amohelehe ho kenya seringana e tšoanang le thiamine le pyridoxine cyanocobalamin solutions.
Morabe oa litšebelisano tse leshome le metso e 'meli
Ts'ebetsong ea Tribedoce (Vitamin B12 (Hydroxocobalamin)) e nang le lithibela-pelehi tsa li-hormone bakeng sa tsamaiso ea molomo e ka fokotsa khatello ea cyanocobalamin ka lero la mali.
Ts'ebetsong ka meriana ea li-anticonvulsant, ho monya cyanocobalamin ke mala ho fokotsehile.
Ts'ebetsong ea Tribedoce (Vitamin B12 (Hydroxocobalamin)) e nang le neomycin, aminosalicylic acid, colchicine, cimetidine, ranitidine, lithethefatsi tsa potasiamo li fokolitse ho monya ha cyanocobalamin maleng.
Cyanocobalamin e ka mpefatsa khatello ea mmele e bakoang ke thiamine.
Ha kopo ea parenteral ea chloramphenicol e ka fokotsa litlamorao tsa lefu la cyanocobalamin le phokolo ea mali.
Ho se lumellane ha meriana
E nang le cobalt ione molek'hule ea cyanocobalamin e tlatsetsa tšenyehong ea ascorbic acid, thiamine bromide, riboflavin ka tharollo.
papatso
Metsoako e sebetsang ea meriana ea Tribedoce e nang le lebitso la lebitso le lithethefatsi tse tloaelehileng tse amanang le tsona:
Sesebelisoa se sebetsang ke karolo ea sethethefatsi kapa sethethefatsi se sebetsang ka biologically. Karolo ena ea lithethefatsi e ikarabella bakeng sa ketso ea mantlha ea moriana o reretsoeng ho folisa kapa ho fokotsa letšoao kapa lefu. Likarolo tse ling tsa moriana o sa sebetseng li bitsoa li-excipients; Karolo ea eona ke ho sebetsa joalo ka koloi kapa binder. Ho fapana le motsoako o sebetsang, karolo ea motsoako o sa sebetseng ha e bohlokoa ho foleng kapa ho phekoleng lefu lena. Ho ka ba le sehlahisoa se le seng kapa ho feta sehlareng.
- Vithamine B1 (thiamine hydrochloride)
- Vithamine B12 (hydroxocobalamin)
- Vithamine B6 (pyridoxine hydrochloride)
Likhamphani tsa morabe oa leshome le metso e 'meli tsa meriana:
Likhamphani tsa meriana ke lik'hamphani tse etsang lithethefatsi tse thusang ho nts'etsapele moriana ka botlalo, ho tloha lipatlisisong tsa morao-rao ho isa koetlisong, liteko tsa bongaka, ho lokolloa ha 'marakeng le ho bapatsa lithethefatsi.
Bafuputsi ke batho ba ikarabellang lipatlisisong tsa mahlale le litekong tsohle tsa bongaka tse fetileng tse bakileng nts'etsopele ea sethethefatsi.
Lipotso tse atisang ho botsoa
Na nka khanna kapa ka sebelisa mechini e boima kamora ho nka Tribedoce?
Ho latela karabelo ea Tribedoce kamora ho e noa, haeba u ikutloa u tsekela, u otsela kapa u etsa letho le fokolang 'meleng oa hau, nahana hore Tribedoce ha e bolokehe ho khanna kapa ho sebelisa mechini e boima kamora ho e sebelisa.
Ho bolelang hore o seke oa khanna kapa oa sebelisa mechini e boima kamora ho nka capsule haeba capsule e na le karabelo e makatsang 'meleng oa hau joalo ka botsoa, ho otsela. Joalokaha ho laetsoe ke rakhemisi, ho kotsi ho noa joala ha u ntse u noa meriana, kaha e pepesetsa bakuli ho otsela le ho beha bophelo ba bona kotsing.
Hlokomela phello ena, haholo ha o noa capsule ea Primosa. Ho bohlokoa hore u botse ngaka ea hau ka nako ho fumana khothatso e nepahetseng le lipuisano tsa bongaka. Na Tribedoce e lemalla kapa e fetoha tloaelo?
Lithethefatsi ha lia etsoa ka sepheo sa ho baka bokhoba kapa tlhekefetso bophelong ba basebelisi. Meriana e lemalloang e bitsoa lintho tse laoloang ke mmuso. Mohlala, Shejulu H kapa X naheng ea India le Shejulu II-V naheng ea United States ke lintho tse laoloang.
Lekola buka ea litaelo ea setlhare mabapi le hore na u ka e sebelisa joang 'me u netefatse hore ha se ntho e laoloang. Qetellong, ho iphekola ho kotsi bophelong ba hau. Ikopanye le ngaka ea hau bakeng sa lengolo le nepahetseng la ngaka, khothaletso le tataiso.
Ho feta tekano
Haeba motho a fetelletsa lintho 'me a e-na le matšoao a matla a kang ho akheha kapa ho hema hanyane, letsetsa 911. Ho seng joalo, letsetsa setsi sa taolo ea chefo hanghang. Baahi ba United States ba ka letsetsa setsi sa bona sa taolo ea chefo ho 1-800-222-1222 . Baahi ba Canada ba ka letsetsa setsi sa taolo ea chefo profinseng. Matšoao a ho feta tekano a ka kenyelletsa: ho oa.
Lintlha
Se ke oa arolelana meriana ena le ba bang. Liteko tsa laboratori le / kapa tsa bongaka (joalo ka palo e felletseng ea mali, liteko tsa ts'ebetso ea liphio) li lokela ho etsoa ha u ntse u sebelisa moriana ona. Boloka linako tsohle tsa bongaka le tsa laboratori.
Polokelo
Sheba litaelo tsa sehlahisoa le setsebi sa metsoako bakeng sa lintlha tsa polokelo. Boloka meriana eohle moo bana le liphoofolo tse ruuoang lapeng ba ke keng ba e fihlela, u se ke ua tšela meriana ka ntlong ea ntloana kapa ua e tšela ka ntle ha e laeloa ho etsa joalo. Lahla sehlahisoa sena hantle ha se felile kapa se sa hlokahale. Ikopanye le rakhemisi kapa k'hamphani ea heno e lahlang litšila.
Boitlhotlhollo: Matona a entse matsapa ohle ho netefatsa hore tlhaiso-leseling eohle e nepahetse, e felletse ebile e nakong. Leha ho le joalo, sengoloa sena ha sea lokela ho sebelisoa ho nka sebaka sa tsebo le boiphihlelo ba setsebi sa tlhokomelo ea bophelo se nang le laesense. Kamehla o lokela ho botsa ngaka ea hau kapa setsebi se seng sa tlhokomelo ea bophelo pele o noa moriana.
Tlhahisoleseling ea lithethefatsi e fumanehang mona e ka fetoha 'me ha ea rereloa ho koahela ts'ebeliso eohle e ka bang teng, litaelo, litemoso, litemoso, likamano tsa lithethefatsi, khatello ea mmele, kapa litlamorao. Ho ba sieo ha litemoso kapa tlhaiso-leseling e 'ngoe bakeng sa moriana o itseng ha ho bontše hore motswako oa sethethefatsi kapa lithethefatsi o bolokehile, oa sebetsa, ebile o loketse bakuli bohle kapa ts'ebeliso eohle e ikhethileng.
LIEKETSENG LITLHAKISO
- DailyMed. ASIDI EA ASCORBIC; BIOTIN; CHOLECALCIFEROL; CYANOCOBALAMIN; DEXPANTHENOL; MOSEBETSI OA MOTSOALLE; NIACINAMIDE; PYRIDOXINE; RIBOFLAVIN; THIAMINE; TOCOPHEROL ACETATE; VITAMIN A; VITAMIN K: DailyMed e fana ka leseli le tšepahalang mabapi le lithethefatsi tse rekisoang United States. DailyMed ke mofani oa semmuso oa leseli la labels ea FDA (liphutheloana tse kenang) .. https://dailymed.nlm.nih.gov/dailyme… (e fihletsoe ka la 17 Loetse, 2018).
- DailyMed. DICLOFENAC EPOLAMINE: DailyMed e fana ka leseli le tšepahalang mabapi le lithethefatsi tse rekisoang United States. DailyMed ke mofani oa semmuso oa leseli la labels ea FDA (liphutheloana tse kenang) .. https://dailymed.nlm.nih.gov/dailyme… (e fihletsoe ka la 17 Loetse, 2018).
- PubChem. diclofenac. https://pubchem.ncbi.nlm.nih.gov/com… (e fihletsoe ka la 17 Loetse 2018).
- PubChem. thiamine. https://pubchem.ncbi.nlm.nih.gov/com… (e fihletsoe ka la 17 Loetse, 2018).
- PubChem. pyridoksine. https://pubchem.ncbi.nlm.nih.gov/com… (e fihletsoeng ka la 17 September, 2018)
Tse ka Hare
- Ketso ea meriana
- Pharmacokinetics
- Hobaneng ha Tribedoce) e laetsoe?
- Tekanyo le tsamaiso
- Morabe litla-morao tse leshome le metso e 'meli, liphetoho tse mpe
- Tribedoce) litemoso
- Tribedoce) nakong ea bokhachane le ho anyesa
- Litaelo tse khethehileng
- Morabe oa litšebelisano tse leshome le metso e 'meli
- Metsoako e sebetsang ea meriana ea Tribedoce e nang le lebitso la lebitso le lithethefatsi tse tloaelehileng tse amanang le tsona:
- Likhamphani tsa morabe oa leshome le metso e 'meli tsa meriana:
- Lipotso tse atisang ho botsoa
- Ho feta tekano
- Lintlha
- Polokelo
- Mantsoe a Khothatso a ka fetolang bophelo ba hau
- E etselitsoe eng? Litekanyo, tšebeliso, litlamorao
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